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KMID : 0377519840090020197
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Chung-Ang Journal of Medicine
1984 Volume.9 No. 2 p.197 ~ p.208
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Effect of Adrenal Steroid on Experimental Myocardial Infarction in Rats
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Koo Kwang-Ho
Lee Sang-Yong
Ryoo Un-Ho
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Abstract
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A number of studies have been performed to reduce myocardial ischemic injury with various pharmacological agents which include β-blockade, nitroglycerin, mannitol, hyaluronidase, glucose-K-insulin and adrenal steroids in the laboratory animal since knowledge of fact that extent of myocardial infarction is closely related to patient survival. The present study was undertaken to investigate how glucocorticoid exert its pharmacological effects on the isoproterenol-induced experimental myocardial infarction in rats. Young rats of the Sprague Dawley strain were used in this investigation and the preliminary study was carried out to establish the normal values of serum enzymes and electrocardiogram in 15 control rats. The experiment was divided into 3 groups, a prednisolone untreated infarction group(80 rats) and a prednisolone single dose treated infarction group(80 rats) and a prednisolone double dose treated infarction group(80 rats). The motality rates, the extent of infarction, changes of serum enzyme level, and electrocardiographic findings were compared between each experimental group. The results were summarized as follows: 1. The mortality rates of rats were 20% in the prednisolone untreated infarction group, 16.3% in the prednisolone single dose treated infarction group and 18.8% in the prednisolone double dose treated infarction group. 2. The extent of myocardial infarction after 36 hours was increased in the prednisolone double dose treated infarction group compared with that of the untreated infarction group. 3. The elevation of serum enzyme in the prednisolone treated infarction group was greater than in the untreated infarction group. 4. The summation of J-point elevation in electrocardiogram after 24 hours was increased in the prednisolone double dose treated infarction group compared with that of the untreated infarction group. 5. The summation of J-point elevation and R wave amplitude showed significant correlation with the extent of myocardial infarction in all study groups. These results suggest that prednisolone exert hazardous effect in the treatment of experimental myocardial infarction in rats.
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